Leipzig have won all six of their Bundesliga matches at home this season and they should have few concerns making that lucky number seven against Cologne.
Leipzig completed a league double over Cologne last season, but conceded on each occasion.
Cologne have failed to score in only two of their 12 league matches this season, which includes recording a 2-1 win at Borussia Dortmund.
RB Leipzig possible starting lineup:
Gulasci; Mukiele, Konate, Upamecano, Angelino; Kampl, Sabitzer; Nkunku, Olmo, Forsberg; Poulsen
FC Koln possible starting lineup:
T. Horn; Cestic, Bornauw, J. Horn; Wolf, Jakobs, Skhiri, Ozcan, Rexhbecaj; Thielmann, Andersson
League: Germany Bundesliga
Match Prediction: RB Leipzig to win